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Article

Evidence for structural symmetry and functional asymmetry in the lactose permease of Escherichia coli.

Biochemistry - 30 Sept 2003

Green Aileen L, Hrodey Heather A, Brooker Robert J

Abstract excerpt

Previous work on the lactose permease of Escherichia coli has shown that mutations along a face of predicted transmembrane segment 8 (TMS-8) play a critical role in conformational changes associated with lactose transport (Green, A. L., and Brooker, R. J. [2001] Biochemistry 40, 12220-12229). Substitutions at positions 261, 265, 268, 272, and 276, which form a continuous stripe along TMS-8, were markedly...

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Identifiers

PMID: 14503872
DOI: 10.1021/bi034810+

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evidence for structural symmetry and functional asymmetry in the lactose permease of Escherichia coli.PMID 14503872Read ↗

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The conserved motif in hydrophilic loop 2/3 and loop 8/9 of the lactose permease of Escherichia coli. Analysis of suppressor mutations.Semantic proximity Read ↗

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