An analysis of suppressor mutations suggests that the two halves of the lactose permease function in a symmetrical manner.

doi:10.1074/jbc.272.42.26110

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Article

An analysis of suppressor mutations suggests that the two halves of the lactose permease function in a symmetrical manner.

The Journal of biological chemistry - 17 Oct 1997

Pazdernik N J, Cain S M, Brooker R J

Abstract excerpt

A conserved motif, GXXX(D/E)(R/K)XG[X](R/K)(R/K), is located in loop 2/3 and loop 8/9 in the lactose permease, and also in hundreds of evolutionarily related transporters. The importance of conserved residues in loop 8/9 was previously investigated (Pazdernik, N. J., Jessen-Marshall, A. E., and B...

Topics

Biological Transport
Escherichia coli Proteins
Genes, Suppressor
Kinetics
Lactose
Membrane Transport Proteins
Monosaccharide Transport Proteins
Mutation
Symporters

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