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Article

Structure and mechanism of the lactose permease of Escherichia coli.

Science (New York, N.Y.) - 1 Aug 2003

Abramson Jeff, Smirnova Irina, Kasho Vladimir, Verner Gillian, Kaback H Ronald, Iwata So

Abstract excerpt

Membrane transport proteins that transduce free energy stored in electrochemical ion gradients into a concentration gradient are a major class of membrane proteins. We report the crystal structure at 3.5 angstroms of the Escherichia coli lactose permease, an intensively studied member of the major facilitator superfamily of transporters. The molecule is composed of N- and C-terminal domains, each with six...

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Identifiers

PMID: 12893935
DOI: 10.1126/science.1088196

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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