Article
Evidence that transmembrane segment 2 of the lactose permease is part of a conformationally sensitive interface between the two halves of the protein.
The Journal of biological chemistry - 19 Jan 1996
Jessen-Marshall A E, Brooker R J
Abstract excerpt
A conserved motif, GXXX(D/E)(R/K)XG(R/K)(R/K), is found in a large group of evolutionarily related membrane proteins involved in the transport of small molecules across the membrane. This motif is located within the cytoplasmic side of transmembrane domain 2 (TM-2) and extends through the hydroph...
Topics
- Amino Acid Sequence
- Base Sequence
- Biological Evolution
- Codon
- Conserved Sequence
- Escherichia coli
- Escherichia coli Proteins
- Genes, Bacterial
- Genes, Suppressor
- Genotype
- Membrane Proteins
- Membrane Transport Proteins
- Models, Structural
- Molecular Sequence Data
- Monosaccharide Transport Proteins
- Mutagenesis, Site-Directed
- Point Mutation
- Protein Structure, Secondary