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Article

The conserved motif, GXXX(D/E)(R/K)XG[X](R/K)(R/K), in hydrophilic loop 2/3 of the lactose permease.

The Journal of biological chemistry - 7 Jul 1995

Jessen-Marshall A E, Paul N J, Brooker R J

Abstract excerpt

A conserved motif, GXXX(D/E)(R/K)XG(R/K)(R/K), has been identified among a large group of evolutionarily related membrane proteins involved in the transport of small molecules across the membrane. To determine the importance of this motif within the lactose permease of Escherichia coli, a total of 28 site-directed mutations at the conserved first, fifth, sixth, eighth, ninth, and tenth positions were analyzed. A...

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PMID: 7608191
DOI: 10.1074/jbc.270.27.16251

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The conserved motif, GXXX(D/E)(R/K)XG[X](R/K)(R/K), in hydrophilic loop 2/3 of the lactose permease.PMID 7608191Read ↗

An analysis of suppressor mutations suggests that the two halves of the lactose permease function in a symmetrical manner.Semantic proximity Read ↗

Evidence that transmembrane segment 2 of the lactose permease is part of a conformationally sensitive interface between the two halves of the protein.Semantic proximity Read ↗

Evidence for structural symmetry and functional asymmetry in the lactose permease of Escherichia coli.Semantic proximity Read ↗

Structural topology of transmembrane helix 10 in the lactose permease of Escherichia coli.Semantic proximity Read ↗

The conserved motif in hydrophilic loop 2/3 and loop 8/9 of the lactose permease of Escherichia coli. Analysis of suppressor mutations.Semantic proximity Read ↗

Suppressor analysis of mutations in the loop 2-3 motif of lactose permease: evidence that glycine-64 is an important residue for conformational changes.Semantic proximity Read ↗

Mutational analysis of putative helix-helix interacting GxxxG-motifs and tryptophan residues in the two-peptide bacteriocin lactococcin G.Semantic proximity Read ↗

A face on transmembrane segment 8 of the lactose permease is important for transport activity.Semantic proximity Read ↗

Identification of essential arginine residues of Escherichia coli DedA/Tvp38 family membrane proteins YqjA and YghB.Semantic proximity Read ↗

The last two cytoplasmic loops in the lactose permease of Escherichia coli comprise a discontinuous epitope for a monoclonal antibody.Semantic proximity Read ↗

Cysteine-scanning mutagenesis of helix II and flanking hydrophilic domains in the lactose permease of Escherichia coli.Semantic proximity Read ↗

Analysis of conserved NCS2 motifs in the Escherichia coli xanthine permease XanQ.Semantic proximity Read ↗

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