A face on transmembrane segment 8 of the lactose permease is important for transport activity.

doi:10.1021/bi0109055

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Article

A face on transmembrane segment 8 of the lactose permease is important for transport activity.

Biochemistry - 9 Oct 2001

Green A L, Brooker R J

Abstract excerpt

Previous work on the lactose permease of Escherichia coli has shown that mutations along a face of predicted transmembrane segment 2 (TMS-2) play a critical role in conformational changes associated with lactose transport [Green, A. L., Anderson, E. J., and Brooker, R. J. (2000) J. Biol. Chem. 275, 23240-23246]. In the current study, mutagenesis was conducted along the side of predicted TMS-8 that contains the...

Topics

Amino Acid Sequence
Biological Transport
Blotting, Western
Escherichia coli
Escherichia coli Proteins
Kinetics
Lactose
Membrane Proteins
Membrane Transport Proteins
Molecular Sequence Data
Monosaccharide Transport Proteins
Mutagenesis, Site-Directed
Phenotype
Symporters

Source

Open in PubMed

Identifiers

PMID: 11580298
DOI: 10.1021/bi0109055

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