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Article

Missense mutations that inactivate Escherichia coli lac permease.

Journal of molecular biology - 27 Mar 1998

Bailey J, Manoil C

Abstract excerpt

Although missense mutations that inactivate integral membrane proteins cause a variety of diseases, the mechanisms by which they act are poorly understood. To establish a model for investigating this issue, we identified 51 missense mutations arising in vivo that inactivate Escherichia coli lac p...

Topics

Base Sequence
Biological Transport
Escherichia coli
Escherichia coli Proteins
Lactose
Membrane Transport Modulators
Membrane Transport Proteins
Models, Biological
Monosaccharide Transport Proteins
Mutagenesis, Site-Directed
Mutation
Symporters

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Identifiers

PMID: 9514765
DOI: 10.1006/jmbi.1998.1627

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9514765-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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