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Article

Mutations of the para sodium channel of Drosophila melanogaster identify putative binding sites for pyrethroids.

Molecular pharmacology - 1 Oct 2003

Vais H, Atkinson S, Pluteanu F, Goodson S J, Devonshire A L, Williamson M S, Usherwood P N R

Abstract excerpt

The effects of two pyrethroids on recombinant wild-type and mutant (pyrethroid-resistant) Na+ channels of Drosophila melanogaster have been studied. Three mutations that confer resistance (kdr/superkdr) to pyrethroids were inserted, either individually or in combination, into the para Na+ channel of D. melanogaster: L1014F in domain IIS6, M918T in the IIS4-S5 linker, and T929I in domain IIS5. Channels were...

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PMID: 14500748
DOI: 10.1124/mol.64.4.914

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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