Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of two kdr mutations at predicted pyrethroid receptor site 2 in the sodium channels of Aedes aegypti and Nilaparvata lugens.

Insect biochemistry and molecular biology - 1 Sept 2022

Sun Huahua, Nomura Yoshiko, Du Yuzhe, Liu Zewen, Zhorov Boris S, Dong Ke

Abstract excerpt

Pyrethroid insecticides prolong the opening of insect sodium channels by binding to two predicted pyrethroid receptor sites (PyR), PyR1 and PyR2. Many naturally-occurring sodium channel mutations that confer pyrethroid resistance (known as knockdown resistance, kdr) are located at PyR1. Recent studies identified two new mutations, V253F and T267A, at PyR2, which co-exist with two well-known mutations F1534C or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aedes
Share to Insecticide Resistance

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Insecticides

Share to Mutation

Share to Pyrethrins

Share to Sodium Channels

Share to Voltage-Gated Sodium Channels

Source

Open in PubMed Open full text

Identifiers

PMID: 35932971
DOI: 10.1016/j.ibmb.2022.103814
PMCID: PMC10076083

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of two kdr mutations at predicted pyrethroid receptor site 2 in the sodium channels of Aedes aegypti and Nilaparvata lugens.PMID 35932971Read ↗

Molecular evidence for dual pyrethroid-receptor sites on a mosquito sodium channel.Semantic proximity Read ↗

Sodium Channel Mutations and Pyrethroid Resistance in Aedes aegyptiSemantic proximity Read ↗

Leucine to tryptophane substitution in the pore helix IIP1 confer sodium channel resistance to pyrethroids and DDT.Semantic proximity Read ↗

Three sodium channel mutations from Aedes albopictus confer resistance to Type I, but not Type II pyrethroids.Semantic proximity Read ↗

Rotational Symmetry of Two Pyrethroid Receptor Sites in the Mosquito Sodium Channel.Semantic proximity Read ↗

A mutation in the intracellular loop III/IV of mosquito sodium channel synergizes the effect of mutations in helix IIS6 on pyrethroid resistance.Semantic proximity Read ↗

Chronology of sodium channel mutations associated with pyrethroid resistance in Aedes aegypti.Semantic proximity Read ↗

Mutations of two acidic residues at the cytoplasmic end of segment IIIS6 of an insect sodium channel have distinct effects on pyrethroid resistance.Semantic proximity Read ↗

Glycine to valine substitution in the short intracellular linkers of domain II enhances I1011M-mediated sodium channel resistance to Type I pyrethroids, but not Type II pyrethroids.Semantic proximity Read ↗

Molecular evidence of sequential evolution of DDT- and pyrethroid-resistant sodium channel in Aedes aegyptiSemantic proximity Read ↗

Global distribution and impact of knockdown resistance mutations in Aedes aegypti on pyrethroid resistance.Semantic proximity Read ↗

Recent advances in the study of knockdown resistance mutations in Aedes mosquitoes with a focus on several remarkable mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.