Point mutations in the Drosophila sodium channel gene para associated with resistance to DDT and pyrethroid insecticides.

doi:10.1007/s004380050608

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Point mutations in the Drosophila sodium channel gene para associated with resistance to DDT and pyrethroid insecticides.

Molecular & general genetics : MGG - 1 Nov 1997

Pittendrigh B, Reenan R, ffrench-Constant R H, Ganetzky B

Abstract excerpt

The gene para in Drosophila melanogaster encodes an alpha subunit of voltage-activated sodium channels, the presumed site of action of DDT and pyrethroid insecticides. We used an existing collection of Drosophila para mutants to examine the molecular basis of targetsite resistance to pyrethroids...

Topics

Alleles
Amino Acid Sequence
Animals
Cockroaches
DDT
Drosophila Proteins
Drosophila melanogaster
Drug Resistance, Multiple
Genes, Dominant
Genes, Insect
Houseflies
Insect Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Insecticide Resistance

Insecticides

Molecular Sequence Data

Paralysis

Point Mutation

Pyrethrins

Source

Open in PubMed

Identifiers

PMID: 9435785
DOI: 10.1007/s004380050608

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9435785-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Point mutations in the Drosophila sodium channel gene para associated with resistance to DDT and pyrethroid insecticides.PMID 9435785Read ↗

Identification of mutations in the housefly para-type sodium channel gene associated with knockdown resistance (kdr) to pyrethroid insecticides.Semantic proximity Read ↗

Mutations of the para sodium channel of Drosophila melanogaster identify putative binding sites for pyrethroids.Semantic proximity Read ↗

The molecular biology of knockdown resistance to pyrethroid insecticides.Semantic proximity Read ↗

Mutations in the Bemisia tabaci para sodium channel gene associated with resistance to a pyrethroid plus organophosphate mixture.Semantic proximity Read ↗

A mutation in the voltage-gated sodium channel gene associated with pyrethroid resistance in Latin American Aedes aegypti.Semantic proximity Read ↗

Overcoming super-knock down resistance (super-kdr) mediated resistance: multi-halogenated benzyl pyrethroids are more toxic to super-kdr than kdr house flies.Semantic proximity Read ↗

Distinct roles of the DmNav and DSC1 channels in the action of DDT and pyrethroids.Semantic proximity Read ↗

Knockdown resistance to DDT and pyrethroids: from target-site mutations to molecular modelling.Semantic proximity Read ↗

Identification of pyrethroid resistance associated mutations in the para sodium channel of the two-spotted spider mite Tetranychus urticae (Acari: Tetranychidae).Semantic proximity Read ↗

The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels.Semantic proximity Read ↗

Characterization of voltage-sensitive sodium channel gene coding sequences from insecticide-susceptible and knockdown-resistant house fly strains.Semantic proximity Read ↗

Drosophila sodium channel mutations: Contributions to seizure-susceptibility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.