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Article

Mutations of two acidic residues at the cytoplasmic end of segment IIIS6 of an insect sodium channel have distinct effects on pyrethroid resistance.

Insect biochemistry and molecular biology - 1 Mar 2017

Chen Mengli, Du Yuzhe, Nomura Yoshiko, Zhu Guonian, Zhorov Boris S, Dong Ke

Abstract excerpt

Mutations in sodium channels are known to confer knockdown resistance to pyrethroid insecticides, such as permethrin and cypermethrin, in various agricultural pests and disease vectors. Double mutations, D3i28V and E3i32G, were detected in cypermethrin-resistant Helicoverpa armigera and Heliothis virescens populations. However, the role of the two mutations in pyrethroid resistance remains unclear. In this study,...

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PMID: 28111191
DOI: 10.1016/j.ibmb.2017.01.007
PMCID: PMC5730327

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