Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct roles of the DmNav and DSC1 channels in the action of DDT and pyrethroids.

Neurotoxicology - 1 Mar 2015

Rinkevich Frank D, Du Yuzhe, Tolinski Josh, Ueda Atsushi, Wu Chun-Fang, Zhorov Boris S, Dong Ke

Abstract excerpt

Voltage-gated sodium channels (Nav channels) are critical for electrical signaling in the nervous system and are the primary targets of the insecticides DDT and pyrethroids. In Drosophila melanogaster, besides the canonical Nav channel, Para (also called DmNav), there is a sodium channel-like cation channel called DSC1 (Drosophila sodium channel 1). Temperature-sensitive paralytic mutations in DmNav (para(ts))...

Topics

Animals
Calcium Channels
DDT
Drosophila Proteins
Drosophila melanogaster
Insecticides
Mutation
Oocytes
Pyrethrins
Sodium Channels
Xenopus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 25687544
DOI: 10.1016/j.neuro.2015.02.001
PMCID: PMC4486006

Genes

DSC1
DDT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct roles of the DmNav and DSC1 channels in the action of DDT and pyrethroids.PMID 25687544Read ↗

DSC1 channel-dependent developmental regulation of pyrethroid susceptibility in Drosophila melanogaster.Semantic proximity Read ↗

Molecular evidence for dual pyrethroid-receptor sites on a mosquito sodium channel.Semantic proximity Read ↗

Leucine to tryptophane substitution in the pore helix IIP1 confer sodium channel resistance to pyrethroids and DDT.Semantic proximity Read ↗

Three sodium channel mutations from Aedes albopictus confer resistance to Type I, but not Type II pyrethroids.Semantic proximity Read ↗

Characterization of two kdr mutations at predicted pyrethroid receptor site 2 in the sodium channels of Aedes aegypti and Nilaparvata lugens.Semantic proximity Read ↗

Glycine to valine substitution in the short intracellular linkers of domain II enhances I1011M-mediated sodium channel resistance to Type I pyrethroids, but not Type II pyrethroids.Semantic proximity Read ↗

Molecular evidence of sequential evolution of DDT- and pyrethroid-resistant sodium channel in Aedes aegyptiSemantic proximity Read ↗

Mutations of the para sodium channel of Drosophila melanogaster identify putative binding sites for pyrethroids.Semantic proximity Read ↗

A mutation in the intracellular loop III/IV of mosquito sodium channel synergizes the effect of mutations in helix IIS6 on pyrethroid resistance.Semantic proximity Read ↗

Alanine to valine substitutions in the pore helix IIIP1 and linker-helix IIIL45 confer cockroach sodium channel resistance to DDT and pyrethroids.Semantic proximity Read ↗

Evidence for Dual Binding Sites for 1,1,1-Trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) in Insect Sodium Channels.Semantic proximity Read ↗

A residue in the transmembrane segment 6 of domain I in insect and mammalian sodium channels regulate differential sensitivities to pyrethroid insecticides.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.