Leucine to tryptophane substitution in the pore helix IIP1 confer sodium channel resistance to pyrethroids and DDT.

doi:10.1016/j.pestbp.2023.105490

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Leucine to tryptophane substitution in the pore helix IIP1 confer sodium channel resistance to pyrethroids and DDT.

Pesticide biochemistry and physiology - 1 Aug 2023

Wu Huiming, Qian Jiali, Xu Zhanyi, Yan Ru, Zhu Guonian, Wu Shaoying, Chen Mengli

Abstract excerpt

Aedes aegypti is responsible for transmitting a variety of arboviral infectious diseases such as dengue and chikungunya. Insecticides, particularly pyrethroids, are used widely for mosquito control. However, intensive used of pyrethroids has led to the selection of kdr mutations on sodium channels. L982W, locating in the PyR1 (Pyrethroid receptor site 1), was first reported in Ae. aegypti populations collected...

Topics

Animals
DDT
Leucine
Pyrethrins
Insecticides
Sodium Channels
Mutation
Insecticide Resistance
Aedes
Mosquito Vectors

Source

Open in PubMed

Identifiers

PMID: 37532317
DOI: 10.1016/j.pestbp.2023.105490

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics