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Article

Alanine to valine substitutions in the pore helix IIIP1 and linker-helix IIIL45 confer cockroach sodium channel resistance to DDT and pyrethroids.

Neurotoxicology - 1 May 2017

Chen Mengli, Du Yuzhe, Nomura Yoshiko, Zhu Guonian, Zhorov Boris S, Dong Ke

Abstract excerpt

Pyrethroid insecticides exert toxic effects by prolonging the opening of voltage-gated sodium channels. More than 20 sodium channel mutations from arthropod pests and disease vectors have been confirmed to confer pyrethroid resistance. These mutations have been valuable in elucidating the molecular interaction between pyrethroids and sodium channels, including identification of two pyrethroid receptor sites....

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Identifiers

PMID: 27328896
DOI: 10.1016/j.neuro.2016.06.009
PMCID: PMC5731473

Genes

DDT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alanine to valine substitutions in the pore helix IIIP1 and linker-helix IIIL45 confer cockroach sodium channel resistance to DDT and pyrethroids.PMID 27328896Read ↗

Mutations of two acidic residues at the cytoplasmic end of segment IIIS6 of an insect sodium channel have distinct effects on pyrethroid resistance.Semantic proximity Read ↗

Glycine to valine substitution in the short intracellular linkers of domain II enhances I1011M-mediated sodium channel resistance to Type I pyrethroids, but not Type II pyrethroids.Semantic proximity Read ↗

A residue in the transmembrane segment 6 of domain I in insect and mammalian sodium channels regulate differential sensitivities to pyrethroid insecticides.Semantic proximity Read ↗

Leucine to tryptophane substitution in the pore helix IIP1 confer sodium channel resistance to pyrethroids and DDT.Semantic proximity Read ↗

Identification of amino acid residues in the insect sodium channel critical for pyrethroid binding.Semantic proximity Read ↗

Three sodium channel mutations from Aedes albopictus confer resistance to Type I, but not Type II pyrethroids.Semantic proximity Read ↗

Differential resistance of insect sodium channels with kdr mutations to deltamethrin, permethrin and DDT.Semantic proximity Read ↗

A mutation in the intracellular loop III/IV of mosquito sodium channel synergizes the effect of mutations in helix IIS6 on pyrethroid resistance.Semantic proximity Read ↗

Mutations of the para sodium channel of Drosophila melanogaster identify putative binding sites for pyrethroids.Semantic proximity Read ↗

Distinct roles of the DmNav and DSC1 channels in the action of DDT and pyrethroids.Semantic proximity Read ↗

Modelling insecticide-binding sites in the voltage-gated sodium channel.Semantic proximity Read ↗

The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels.Semantic proximity Read ↗

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