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Article

Tumor necrosis factor gene polymorphism is associated with enhanced systemic inflammatory response and increased cardiopulmonary morbidity after cardiac surgery.

Anesthesia and analgesia - 1 Oct 2003

Tomasdottir Hildur, Hjartarson Hjörtur, Ricksten Anne, Wasslavik Carina, Bengtsson Anders, Ricksten Sven-Erik

Abstract excerpt

UNLABELLED: Cardiopulmonary bypass induces a systemic inflammatory response characterized by alterations in cardiopulmonary function. Mediators for this morbidity are the cytokines tumor necrosis factor (TNF)-alpha and interleukins. A genomic polymorphism within the TNF locus is associated with increased TNF-alpha levels and high mortality in severe trauma and sepsis. We assessed the relationship of biallelic...

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PMID: 14500138
DOI: 10.1213/01.ANE.0000078574.76915.11

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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