Article
Tumor necrosis factor gene polymorphism is associated with enhanced systemic inflammatory response and increased cardiopulmonary morbidity after cardiac surgery.
Anesthesia and analgesia - 1 Oct 2003
Tomasdottir Hildur, Hjartarson Hjörtur, Ricksten Anne, Wasslavik Carina, Bengtsson Anders, Ricksten Sven-Erik
Abstract excerpt
UNLABELLED: Cardiopulmonary bypass induces a systemic inflammatory response characterized by alterations in cardiopulmonary function. Mediators for this morbidity are the cytokines tumor necrosis factor (TNF)-alpha and interleukins. A genomic polymorphism within the TNF locus is associated with i...
Topics
- Adult
- Aged
- Aged, 80 and over
- Anesthesia, General
- Cardiac Surgical Procedures
- DNA
- DNA Primers
- Female
- Genotype
- Heart Diseases
- Humans
- Inflammation
- Inflammation Mediators
- Interleukin-6
- Lung Diseases
- Lymphotoxin-alpha
- Male
- Middle Aged