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Article

Influence of the TNF-alpha and TNF-beta polymorphisms upon infectious risk and outcome in surgical intensive care patients.

Surgical infections - 1 Jan 2003

Calvano Jacqueline E, Um John Y, Agnese Doreen M, Hahm Sae J, Kumar Ashwini, Coyle Susette M, Calvano Steve E, Lowry Stephen F

Abstract excerpt

BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) is a well-documented central inflammatory mediator in sepsis. Specific polymorphisms of the TNF-alpha and TNF-beta genes (TNF2 and LTA + 250, respectively) have been suggested to correlate with higher mortality in septic shock. This study sought to determine whether these polymorphisms of the TNF-alpha and -beta genes are associated with an increased risk of...

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Source

Identifiers

PMID: 12906716
DOI: 10.1089/109629603766956951

Genes

TNF
LTA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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