Tumor necrosis factor-α -863 C/A promoter polymorphism affects the inflammatory response after cardiac surgery.

doi:10.1016/j.ejcts.2011.01.084

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Article

Tumor necrosis factor-α -863 C/A promoter polymorphism affects the inflammatory response after cardiac surgery.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery - 1 Jul 2011

Boehm Johannes, Hauner Katharina, Grammer Joachim, Dietrich Wulf, Wagenpfeil Stefan, Braun Siegmund, Lange Rüdiger, Bauernschmitt Robert

Abstract excerpt

OBJECTIVE: Cardiac surgery using cardiopulmonary bypass (CPB) initiates an inflammatory response that shows a wide inter-individual range and determines postoperative morbidity. Previous research suggests that genetic diversity contributes to individual susceptibility to perioperative trauma and stress. Nevertheless, the genetic triggering of the tumor necrosis factor-alpha (TNF-α) release remains unclear. We...

Topics

Aged
Aged, 80 and over
Cardiopulmonary Bypass
Coronary Artery Bypass
Genetic Predisposition to Disease
Genotype
Humans
Inflammation
Inflammation Mediators
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Perioperative Care

Polymorphism, Single Nucleotide

Promoter Regions, Genetic

Prospective Studies

Treatment Outcome

Tumor Necrosis Factor-alpha

Source

Open in PubMed

Identifiers

PMID: 21450487
DOI: 10.1016/j.ejcts.2011.01.084

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-21450487-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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