Article
Mutations in the small subunit of the Drosophila U2AF splicing factor cause lethality and developmental defects.
Proceedings of the National Academy of Sciences of the United States of America - 17 Sept 1996
Rudner D Z, Kanaar R, Breger K S, Rio D C
Abstract excerpt
The essential eukaryotic pre-mRNA splicing factor U2AF (U2 small nuclear ribonucleoprotein auxiliary factor) is required to specify the 3' splice at an early step in spliceosome assembly. U2AF binds site-specifically to the intron polypyrimidine tract and recruits U2 small nuclear ribonucleoprote...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Animals, Genetically Modified
- DNA Transposable Elements
- Drosophila melanogaster
- Female
- Genes, Insect
- Genes, Lethal
- Genetic Complementation Test
- Humans
- Male
- Molecular Sequence Data
- Mutagenesis
- Nuclear Proteins
- RNA Precursors
- RNA Splicing
- Ribonucleoproteins