Article
Family study of alpha 1-antitrypsin deficiency: effects of cigarette smoking, measured genotype, and their interaction on pulmonary function and biochemical traits.
Genetic epidemiology - 1 Jan 1992
Silverman E K, Province M A, Campbell E J, Pierce J A, Rao D C
Abstract excerpt
To gain insight into the variable expression of lung disease in alpha 1-antitrypsin (alpha 1AT) deficiency, five quantitative variables including forced expiratory volume at 1 sec (FEV1), forced expiratory flow rate between 25 and 75% of forced vital capacity (FEF25-75), total serum alpha 1AT, oxidized serum alpha 1AT, and total serum immunoglobulin E (IgE) were measured in alpha 1AT deficient individuals and...
Topics
- Family
- Female
- Fluorescent Antibody Technique
- Genotype
- Humans
- Immunoglobulin E
- Lung Diseases, Obstructive
- Male
- Phenotype
- Pulmonary Emphysema
- Respiratory Mechanics