Article
Interactions between SERPINA1 PiMZ genotype, occupational exposure and lung function decline.
Occupational and environmental medicine - 1 Apr 2014
Mehta A J, Thun G A, Imboden M, Ferrarotti I, Keidel D, Künzli N, Kromhout H, Miedinger D, Phuleria H, Rochat T, Russi E W, Schindler C, Schwartz J, Vermeulen R, Luisetti M, Probst-Hensch N
Abstract excerpt
OBJECTIVES: We evaluated interactions between SERPINA1 PiMZ genotype, associated with intermediate α1-antitrysin deficiency, with outdoor particulate matter ≤10 µm (PM10), and occupational exposure to vapours, dusts, gases and fumes (VGDF), and their effects on annual change in lung function. METHODS: Pre-bronchodilator spirometry was performed in 3739 adults of the Swiss Cohort Study on Air Pollution and Lung...
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