Longitudinal Outcomes in Pi*MZ Alpha-1 Antitrypsin-Deficient Individuals with Tobacco Smoking History from the SPIROMICS Cohort.

doi:10.1513/AnnalsATS.202411-1209OC

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Article

Longitudinal Outcomes in Pi*MZ Alpha-1 Antitrypsin-Deficient Individuals with Tobacco Smoking History from the SPIROMICS Cohort.

Annals of the American Thoracic Society - 1 Jul 2025

Barjaktarevic Igor, Hixson Roxana, Zhuang Zian, Buhr Russell G, Tejwani Vickram, Barr R Graham, Bateman Lori A, Bhatt Surya P, Bleecker Eugene R, Cooper Christopher B, Curtis Jeffrey L, Drummond M Bradley, Fortis Spyridon, Ghosh Auyon J, Han MeiLan, Hansel Nadia N, Hoffman Eric A, Ohar Jill, Martinez Fernando J, Meyers Deborah A, Paine Robert, Pirozzi Cheryl S, Sandhaus Robert, Strange Charlie, Tashkin Donald P, Wells J Michael, Woodruff Prescott, Ortega Victor E

Abstract excerpt

Rationale: Reliable data about the natural history of lung function decline in alpha-1 antitrypsin (AAT)-deficient Pi*MZ heterozygotes is largely missing. Objectives: We hypothesized that, in adults with a tobacco smoking history, lung function deteriorates faster in Pi*MZ compared with the Pi*MM genotype. Methods: We identified 1,856 Pi*MM and 79 Pi*MZ participants with ⩾20 pack-years tobacco smoking history...

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PMID: 40068143
DOI: 10.1513/AnnalsATS.202411-1209OC
PMCID: PMC12254153

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