Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic differences in alpha 1 antitrypsin-deficient sibling pairs may relate to genetic variation.

COPD - 1 Dec 2008

Wood Alice M, Needham Michelle, Simmonds Matthew J, Newby Paul R, Gough Stephen C, Stockley Robert A

Abstract excerpt

Alpha-1-antitrypsin deficiency is associated with variable development of airflow obstruction and emphysema. Index patients have greater airflow obstruction than subjects detected by screening, but it is unclear if this reflects smoking differences and/or ascertainment bias, or is due to additional genetic factors. In this study 72 sibling pairs with alpha-1-antitrypsin deficiency were compared using lung...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha 1-Antitrypsin Deficiency
Share to Forced Expiratory Volume

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Pulmonary Disease, Chronic Obstructive

Share to Pulmonary Emphysema

Share to Pulmonary Surfactant-Associated Protein B

Share to Transforming Growth Factor beta

Share to Vital Capacity

Share to Vitamin D-Binding Protein

Source

Identifiers

PMID: 19353349
DOI: 10.1080/15412550802522320

Genes

FEV

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic differences in alpha 1 antitrypsin-deficient sibling pairs may relate to genetic variation.PMID 19353349Read ↗

Familial risks for chronic obstructive pulmonary disease among siblings based on hospitalisations in Sweden.Semantic proximity Read ↗

Development of predictive models for airflow obstruction in alpha-1-antitrypsin deficiency.Semantic proximity Read ↗

Genetics of chronic obstructive pulmonary disease, beyond a1-antitrypsin deficiency.Semantic proximity Read ↗

Recent advances in α-1-antitrypsin deficiency-related lung disease.Semantic proximity Read ↗

Novel strategy to identify genetic risk factors for COPD severity: a genetic isolate.Semantic proximity Read ↗

Genetic risk factors for chronic obstructive pulmonary diseaseSemantic proximity Read ↗

Alpha1-antitrypsin deficiency alleles and the Taq-I G-->A allele in cystic fibrosis lung disease.Semantic proximity Read ↗

[Genetic risk factors for chronic obstructive pulmonary disease (COPD)].Semantic proximity Read ↗

Linkage analysis of alpha 1-antitrypsin deficiency: lessons for complex diseases.Semantic proximity Read ↗

IL10 polymorphisms are associated with airflow obstruction in severe alpha1-antitrypsin deficiency.Semantic proximity Read ↗

Applying whole-genome sequencing in relation to phenotype and outcomes in siblings with cystic fibrosis.Semantic proximity Read ↗

[Two sisters with lung emphysema].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.