Article
Impact of non-linear smoking effects on the identification of gene-by-smoking interactions in COPD genetics studies.
Thorax - 1 Oct 2011
Castaldi P J, Demeo D L, Hersh C P, Lomas D A, Soerheim I C, Gulsvik A, Bakke P, Rennard S, Pare P, Vestbo J, Silverman E K
Abstract excerpt
BACKGROUND: The identification of gene-by-environment interactions is important for understanding the genetic basis of chronic obstructive pulmonary disease (COPD). Many COPD genetic association analyses assume a linear relationship between pack-years of smoking exposure and forced expiratory volume in 1 s (FEV(1)); however, this assumption has not been evaluated empirically in cohorts with a wide spectrum of...
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