Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

COPD in individuals with the PiMZ alpha-1 antitrypsin genotype.

European respiratory review : an official journal of the European Respiratory Society - 31 Dec 2017

Al Ashry Haitham S, Strange Charlie

Abstract excerpt

Since the discovery of severe alpha-1 antitrypsin deficiency as a genetic risk factor for emphysema, there has been ongoing debate over whether individuals with intermediate deficiency with one protease inhibitor Z allele (PiMZ, or MZ) are at some risk for emphysema. This is important, because MZ individuals comprise 2-5% of the general population. In this review we summarise the evidence about the risks of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha 1-Antitrypsin
Share to alpha 1-Antitrypsin Deficiency

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Asthma

Share to Gene-Environment Interaction

Share to Pulmonary Disease, Chronic Obstructive

Share to Pulmonary Emphysema

Share to Smoking

Source

Open in PubMed Open full text

Identifiers

PMID: 29070580
DOI: 10.1183/16000617.0068-2017
PMCID: PMC9488576

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

COPD in individuals with the PiMZ alpha-1 antitrypsin genotype.PMID 29070580Read ↗

Clarification of the risk of chronic obstructive pulmonary disease in α1-antitrypsin deficiency PiMZ heterozygotes.Semantic proximity Read ↗

α₁-Antitrypsin protease inhibitor MZ heterozygosity is associated with airflow obstruction in two large cohorts.Semantic proximity Read ↗

Estimated Prevalence and Number of PiMZ Genotypes of Alpha-1 Antitrypsin in Seventy-Four Countries Worldwide.Semantic proximity Read ↗

PiSZ alpha-1 antitrypsin deficiency (AATD): pulmonary phenotype and prognosis relative to PiZZ AATD and PiMM COPD.Semantic proximity Read ↗

Alpha-1 antitrypsin (AAT) augmentation therapy in individuals with the PI*MZ genotype: a pro/con debate on a working hypothesis.Semantic proximity Read ↗

Longitudinal lung function study in heterozygous PiMZ phenotype subjects.Semantic proximity Read ↗

SERPINA1 PiZ and PiS heterozygotes and lung function decline in the SAPALDIA cohort.Semantic proximity Read ↗

Risk of Lung Disease in PI MZ Heterozygotes. Current Status and Future Research Directions.Semantic proximity Read ↗

Risk of hospital admission for obstructive pulmonary disease in alpha(1)-antitrypsin heterozygotes of phenotype PiMZ.Semantic proximity Read ↗

Alpha-1 Antitrypsin MZ Heterozygosity Is an Endotype of Chronic Obstructive Pulmonary Disease.Semantic proximity Read ↗

Change in lung function and morbidity from chronic obstructive pulmonary disease in alpha1-antitrypsin MZ heterozygotes: A longitudinal study of the general population.Semantic proximity Read ↗

α1-Antitrypsin deficiency and chronic respiratory disorders.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.