Article
A family study of the variability of pulmonary function in alpha 1-antitrypsin deficiency. Quantitative phenotypes.
The American review of respiratory disease - 1 Nov 1990
Silverman E K, Province M A, Rao D C, Pierce J A, Campbell E J
Abstract excerpt
A group of 52 alpha 1-antitrypsin-deficient individuals of phenotype Pi Z and 117 of their relatives underwent a protocol including pulmonary function testing, completion of a questionnaire, and blood donation. Our population permitted a minimum frequency estimate (7 x 10(-4)) for Pi null alleles. Five quantitative phenotypes were measured, including FEV1, FEF25-75, total serum alpha 1AT, oxidized serum alpha...
Topics
- Adult
- Female
- Forced Expiratory Volume
- Humans
- Immunoglobulin E
- Lung Diseases, Obstructive
- Male
- Maximal Expiratory Flow Rate
- Phenotype
- Pulmonary Ventilation
- Smoking