Article
Biochemical intermediates in alpha 1-antitrypsin deficiency: residual family resemblance for total alpha 1-antitrypsin, oxidized alpha 1-antitrypsin, and immunoglobulin E after adjustment for the effect of the Pi locus.
Genetic epidemiology - 1 Jan 1990
Silverman E K, Province M A, Campbell E J, Pierce J A, Rao D C
Abstract excerpt
alpha 1-antitrypsin (alpha 1 AT) deficiency is variably associated with the development of pulmonary emphysema. To gain insight into the process which begins the Z point mutation at the Protease Inhibitor (Pi) locus and results in the variable development of emphysema, three quantitative phenotyp...
Topics
- Data Interpretation, Statistical
- Female
- Humans
- Immunoglobulin E
- Male
- Models, Genetic
- Oxidation-Reduction
- Pedigree
- Phenotype
- Pulmonary Emphysema
- alpha 1-Antitrypsin
- alpha 1-Antitrypsin Deficiency