Variability of pulmonary function in alpha-1-antitrypsin deficiency: residual family resemblance beyond the effect of the Pi locus.

doi:10.1159/000153958

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Article

Variability of pulmonary function in alpha-1-antitrypsin deficiency: residual family resemblance beyond the effect of the Pi locus.

Human heredity - 1 Jan 1990

Silverman E K, Province M A, Campbell E J, Pierce J A, Rao D C

Abstract excerpt

To gain insight into the variable expression of lung disease in alpha 1-antitrypsin deficiency, two pulmonary function tests, FEV1 and FEF25-75, were examined in alpha 1-antitrypsin-deficient individuals and their families. The mean and variance effects of Pi type, age, and sex on the pulmonary f...

Topics

Factor Analysis, Statistical
Forced Expiratory Volume
Genotype
Humans
Lung
Maximal Midexpiratory Flow Rate
Models, Genetic
Smoking
alpha 1-Antitrypsin

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