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Article

APC germline mutations identified in Czech patients with familial adenomatous polyposis.

Human mutation - 1 Apr 2002

Kohoutová Milada, Stekrová Jitka, Jirásek Václav, Kapras Jan

Abstract excerpt

Familial adenomatous polyposis (FAP) is an autosomal dominantly inherited predisposition to colorectal cancer, which is caused by germline mutations in the adenomatous polyposis coli (APC) gene. The APC mutations have been investigated in 46 Czech unrelated FAP families and 9 suspected FAP families using DGGE analysis and direct DNA sequencing. We found 25 germline APC mutations and identified 11 which were not...

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Source

Identifiers

PMID: 11933206
DOI: 10.1002/humu.9028

Genes

APC
FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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