Article
Analysis of VH251 gene mutation in chronic lymphocytic leukemia (CLL) and normal B-cell subsets.
Annals of the New York Academy of Sciences - 4 May 1992
Cai J, Humphries C, Lutz C, Tucker P W
Abstract excerpt
B-cell chronic lymphocytic leukemia (CLL) is the malignant, monoclonal equivalent of a human CD5+ B cell. Previous studies have shown that the VH and VL genes rearranged and/or expressed in CLL have low and random mutations. In this study, however, we have found that the rearranged VH251 gene, on...
Topics
- B-Lymphocyte Subsets
- Base Sequence
- Cloning, Molecular
- DNA
- DNA, Neoplasm
- Gene Rearrangement
- Genes, Immunoglobulin
- Humans
- Leukemia, Lymphocytic, Chronic, B-Cell
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides