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Article

Analysis of VH251 gene mutation in chronic lymphocytic leukemia (CLL) and normal B-cell subsets.

Annals of the New York Academy of Sciences - 4 May 1992

Cai J, Humphries C, Lutz C, Tucker P W

Abstract excerpt

B-cell chronic lymphocytic leukemia (CLL) is the malignant, monoclonal equivalent of a human CD5+ B cell. Previous studies have shown that the VH and VL genes rearranged and/or expressed in CLL have low and random mutations. In this study, however, we have found that the rearranged VH251 gene, one of the three-membered VH5 family, has extensive and selective mutations in B-CLL cells. Somatic mutation at the...

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Identifiers

PMID: 1599132
DOI: 10.1111/j.1749-6632.1992.tb24639.x

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Analysis of VH251 gene mutation in chronic lymphocytic leukemia (CLL) and normal B-cell subsets.PMID 1599132Read ↗

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