Article
Structural aspects of human IgM antibodies expressed in chronic B lymphocytic leukemia.
Immunotechnology : an international journal of immunological engineering - 1 Mar 1999
Ramsland P A, Brock C R, Moses J, Robinson B G, Edmundson A B, Raison R L
Abstract excerpt
BACKGROUND: Malignant B cells from patients with chronic B lymphocytic leukemia (B CLL) generally express both surface IgM and the pan T cell antigen CD5, a characteristic of the B1 population of B lymphocytes. The IgM on the surface of these B CLL cells is frequently polyreactive with respect to its capacity to recognize multiple structurally dissimilar antigens (Ag). OBJECTIVES: To understand the structural...
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