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Article

Human chromosome 11 contains two different growth suppressor genes for embryonal rhabdomyosarcoma.

1 Mar 1992

Abstract excerpt

The identification of acquired homozygosity in human cancers implies locations of tumor suppressor genes without providing functional evidence. The localization of a defect in embryonal rhabdomyosarcomas to chromosomal region 11p15 provides one such example. In this report, we show that transfer of a normal human chromosome 11 into an embryonal rhabdomyosarcoma cell line elicited a dramatic loss of the...

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Identifiers

PMID: 1347425
DOI: 10.1073/pnas.89.5.1755

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Source receipt: pubmed, retrieved 7 Sept 2026.

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