Article
Loss of heterozygosity on chromosome 7q and aggressive primary breast cancer.
Lancet (London, England) - 18 Jan 1992
Bièche I, Champème M H, Matifas F, Hacène K, Callahan R, Lidereau R
Abstract excerpt
Genetic alterations are believed to be important in the origin and dissemination of breast cancer. Cytogenetic rearrangements on chromosome 7 are common in breast tumours. We used the c-met proto-oncogene probe, which detects sequences on chromosome 7q31, to analyse tumour and blood leucocyte DNA...
Topics
- Alleles
- Analysis of Variance
- Breast Neoplasms
- Chromosome Deletion
- Chromosomes, Human, Pair 7
- DNA, Neoplasm
- Female
- Follow-Up Studies
- Heterozygote
- Humans
- Mutation
- Polymorphism, Restriction Fragment Length