Human chromosome 11 inhibits tumorigenicity of a murine squamous cell carcinoma cell line.

doi:10.1002/gcc.2870130108

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Article

Human chromosome 11 inhibits tumorigenicity of a murine squamous cell carcinoma cell line.

Genes, chromosomes & cancer - 1 May 1995

Zenklusen J C, Oshimura M, Barrett J C, Conti C J

Abstract excerpt

Loss of heterozygosity (LOH) of mouse chromosome 7 has been consistently demonstrated in chemically induced murine squamous cell carcinomas (SCCs). The region of this chromosome presenting LOH in the mouse tumors is syntenic to human chromosome segments 11p15 and 11q. To determine whether the introduction of human chromosome (Hchr) 11 can suppress the growth of murine SCC, we injected four clones of a chemically...

Topics

Alleles
Animals
Carcinoma, Squamous Cell
Cell Division
Cell Transformation, Neoplastic
Chromosome Deletion
Chromosomes, Human, Pair 11
Disease Models, Animal
Genes, Tumor Suppressor
Heterozygote
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

In Situ Hybridization, Fluorescence

Mice

Mice, Inbred BALB C

Mice, Nude

Polymerase Chain Reaction

Transfection

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 7541643
DOI: 10.1002/gcc.2870130108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7541643-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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