Article
Aberrant expression and localization of the RAP1 shelterin protein contribute to age-related phenotypes.
PLoS genetics - 1 Nov 2022
Stock Amanda J, McDevitt Ross A, Puligilla Chandrakala, Wang Yajun, Zhang Yongqing, Wang Kun, Sun Chongkui, Becker Kevin G, Lehrmann Elin, Wood William H, Gong Yi, Aqdas Mohammad, Sung Myong-Hee, Hoffmann Victoria, Liu Chengyu, Gorospe Myriam, Harrington Lea, Ferrucci Luigi, Liu Yie
Abstract excerpt
Short telomeres induce a DNA damage response (DDR) that evokes apoptosis and senescence in human cells. An extant question is the contribution of telomere dysfunction-induced DDR to the phenotypes observed in aging and telomere biology disorders. One candidate is RAP1, a telomere-associated protein that also controls transcription at extratelomeric regions. To distinguish these roles, we generated a knockin mouse...
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