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Article

Rap1 protein regulates telomere turnover in yeast.

Proceedings of the National Academy of Sciences of the United States of America - 13 Oct 1998

Krauskopf A, Blackburn E H

Abstract excerpt

Telomere length is maintained through a dynamic balance between addition and loss of the terminal telomeric DNA. Normal telomere length regulation requires telomerase as well as a telomeric protein-DNA complex. Previous work has provided evidence that in the budding yeasts Kluyveromyces lactis and Saccharomyces cerevisiae, the telomeric double-stranded DNA binding protein Rap1p negatively regulates telomere...

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Identifiers

PMID: 9770512
DOI: 10.1073/pnas.95.21.12486
PMCID: PMC22857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rap1 protein regulates telomere turnover in yeast.PMID 9770512Read ↗

Regulation of telomere length by an N-terminal region of the yeast telomerase reverse transcriptase.Semantic proximity Read ↗

C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae.Semantic proximity Read ↗

A genetic interaction between RAP1 and telomerase reveals an unanticipated role for RAP1 in telomere maintenanceSemantic proximity Read ↗

A protein-counting mechanism for telomere length regulation in yeast.Semantic proximity Read ↗

Telomerase, the recombination machinery and Rap1 play redundant roles in yeast telomere protection.Semantic proximity Read ↗

The telomere and telomerase: how do they interact?Semantic proximity Read ↗

Dynamics of telomeric DNA turnover in yeast.Semantic proximity Read ↗

Mutant telomeres inhibit transcriptional silencing at native telomeres of the yeast Kluyveromyces lactis.Semantic proximity Read ↗

The telomere and telomerase: nucleic acid-protein complexes acting in a telomere homeostasis system. A review.Semantic proximity Read ↗

Mutational analysis defines a C-terminal tail domain of RAP1 essential for Telomeric silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Aberrant expression and localization of the RAP1 shelterin protein contribute to age-related phenotypes.Semantic proximity Read ↗

A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae.Semantic proximity Read ↗

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