Article
The upstream region of the human gamma-globin gene promoter. Identification and functional analysis of nuclear protein binding sites.
The Journal of biological chemistry - 25 Jun 1991
McDonagh K T, Lin H J, Lowrey C H, Bodine D M, Nienhuis A W
Abstract excerpt
The promoter of the human gamma-globin gene confers tissue specificity as well as developmental stage specificity to gamma gene expression. Earlier work in our laboratory suggested that a fragment of the gamma-globin promoter between -300 and -137 base pairs upstream of the transcription start si...
Topics
- Base Sequence
- Binding Sites
- DNA Fingerprinting
- DNA, Neoplasm
- Globins
- HeLa Cells
- Humans
- Leukemia, Erythroblastic, Acute
- Methylation
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Promoter Regions, Genetic
- Regulatory Sequences, Nucleic Acid
- Transcription, Genetic