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Article

A GC-box is required for expression of the human vimentin gene.

Gene - 22 Jul 1999

Izmailova E S, Wieczorek E, Perkins E B, Zehner Z E

Abstract excerpt

Vimentin is an intermediate filament protein normally expressed in cells of mesenchymal origin. The promoter of the human vimentin gene (-1416 to +73) was shown to contain two positive-acting regions, separated by a negative region, and at least eight GC-boxes as determined by sequence homology (Rittling, S.R., Baserga, R., 1987. Mol. Cell. Biol. 7, 3908-3915). We have analyzed the region -900 to +41 for protein...

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PMID: 10415334
DOI: 10.1016/s0378-1119(99)00209-7

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