Myotube-specific activity of the human aldolase A M-promoter requires an overlapping binding site for NF1 and MEF2 factors in addition to a binding site (M1) for unknown proteins.

doi:10.1006/jmbi.1995.0532

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Myotube-specific activity of the human aldolase A M-promoter requires an overlapping binding site for NF1 and MEF2 factors in addition to a binding site (M1) for unknown proteins.

Journal of molecular biology - 13 Oct 1995

Salminen M, Spitz F, Fiszman M Y, Demignon J, Kahn A, Daegelen D, Maire P

Abstract excerpt

The human aldolase A gene is expressed in several tissues through the use of three alternative promoters. The activity of one of the promoters, pM, is restricted to skeletal muscle. We reported previously that a proximal 280 bp pM fragment confers tissue-specific expression to a CAT reporter gene in transgenic mice. This small regulatory region directs expression to muscle composed mainly of fast-twitch fibers....

Topics

Animals
Base Sequence
Binding Sites
Cell Differentiation
Cells, Cultured
DNA Footprinting
DNA-Binding Proteins
Fructose-Bisphosphate Aldolase
Gene Expression Regulation, Developmental
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Liver

MEF2 Transcription Factors

Mice

Molecular Sequence Data

Muscle Fibers, Fast-Twitch

Mutation

Myogenic Regulatory Factors

Neurofibromin 1

Source

Open in PubMed

Identifiers

PMID: 7473711
DOI: 10.1006/jmbi.1995.0532

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7473711-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Myotube-specific activity of the human aldolase A M-promoter requires an overlapping binding site for NF1 and MEF2 factors in addition to a binding site (M1) for unknown proteins.PMID 7473711Read ↗

Fast-muscle-specific DNA-protein interactions occurring in vivo at the human aldolase A M promoter are necessary for correct promoter activity in transgenic mice.Semantic proximity Read ↗

Analysis of upstream regulatory regions required for the activities of two promoters of the rat aldolase A gene.Semantic proximity Read ↗

Proximal sequences of the aldolase A fast muscle-specific promoter direct nerve- and activity-dependent expression in transgenic mice.Semantic proximity Read ↗

Mouse muscle identity: the position-dependent and fast fiber-specific expression of a transgene in limb muscles is methylation-independent and cell-autonomous.Semantic proximity Read ↗

Transcription Enhancer Factor 1 Binds Multiple Muscle MEF2 and A/T-Rich Elements during Fast-to-Slow Skeletal Muscle Fiber Type TransitionsSemantic proximity Read ↗

Alpha-actinin 4 and BAT1 interaction with the cytochrome c promoter upon skeletal muscle differentiation.Semantic proximity Read ↗

M-CAT binding factor, a novel trans-acting factor governing muscle-specific transcription.Semantic proximity Read ↗

Structural and functional analysis of myostatin-2 promoter alleles from the marine fish Sparus aurata: evidence for strong muscle-specific promoter activity and post-transcriptional regulation.Semantic proximity Read ↗

Two adjacent MyoD1-binding sites regulate expression of the acetylcholine receptor alpha-subunit gene.Semantic proximity Read ↗

A 40-kilodalton protein binds specifically to an upstream sequence element essential for muscle-specific transcription of the human myoglobin promoter.Semantic proximity Read ↗

Acetylcholinesterase Expression in Muscle Is Specifically Controlled by a Promoter-Selective Enhancesome in the First IntronSemantic proximity Read ↗

Identification of a tissue-specific regulatory element within the human muscle glycogen phosphorylase gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.