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Article

The basic region of myogenin cooperates with two transcription activation domains to induce muscle-specific transcription.

Molecular and cellular biology - 1 Jan 1992

Schwarz J J, Chakraborty T, Martin J, Zhou J M, Olson E N

Abstract excerpt

Myogenin is a skeletal muscle-specific transcription factor that can activate myogenesis when introduced into a variety of nonmuscle cell types. Activation of the myogenic program by myogenin is dependent on its binding to a DNA sequence known as an E box, which is associated with numerous muscle-specific genes. Myogenin shares homology with MyoD and other myogenic regulatory factors within a basic region and a...

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Identifiers

PMID: 1309591
DOI: 10.1128/mcb.12.1.266-275.1992
PMCID: PMC364092

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The basic region of myogenin cooperates with two transcription activation domains to induce muscle-specific transcription.PMID 1309591Read ↗

Repression of myogenin function by TGF-beta 1 is targeted at the basic helix-loop-helix motif and is independent of E2A products.Semantic proximity Read ↗

Determinants of myogenic specificity within MyoD are required for noncanonical E box binding.Semantic proximity Read ↗

HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors.Semantic proximity Read ↗

Dimerization specificity of myogenic helix-loop-helix DNA-binding factors directed by nonconserved hydrophilic residues.Semantic proximity Read ↗

Runx1 Transcription Factor Is Required for Myoblasts Proliferation during Muscle RegenerationSemantic proximity Read ↗

Establishment of distinct MyoD, E2A, and twist DNA binding specificities by different basic region-DNA conformations.Semantic proximity Read ↗

Crystal structure of human GDF11Semantic proximity Read ↗

Myogenin resides in the nucleus and acquires high affinity for a conserved enhancer element on heterodimerization.Semantic proximity Read ↗

Transcription Factor Rational Design Improves Directed Differentiation of Human Mesenchymal Stem Cells Into Skeletal MyocytesSemantic proximity Read ↗

MSX1 cooperates with histone H1b for inhibition of transcription and myogenesis.Semantic proximity Read ↗

TEAD transcription factors are required for normal primary myoblast differentiation in vitro and muscle regeneration in vivo.Semantic proximity Read ↗

MyoD uses overlapping but distinct elements to bind E-box and tetraplex structures of regulatory sequences of muscle-specific genes.Semantic proximity Read ↗

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