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Article

Human immunodeficiency virus type 1 pathogenesis in SCID-hu mice correlates with syncytium-inducing phenotype and viral replication.

Journal of virology - 1 Apr 2000

Camerini D, Su H P, Gamez-Torre G, Johnson M L, Zack J A, Chen I S

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) patient isolates and molecular clones were used to analyze the determinants responsible for human CD4(+) thymocyte depletion in SCID-hu mice. Non-syncytium-inducing, R5 or R3R5 HIV-1 isolates from asymptomatic infected people showed little or no human CD4(+) thymocyte depletion in SCID-hu mice, while syncytium-inducing (SI), R5X4 or R3R5X4 HIV-1 isolates from the same...

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Identifiers

PMID: 10708436
DOI: 10.1128/jvi.74.7.3196-3204.2000
PMCID: PMC111820

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