Transcription of viral late genes is dependent on expression of the viral intermediate gene G8R in cells infected with an inducible conditional-lethal mutant vaccinia virus.

doi:10.1128/JVI.66.11.6470-6479.1992

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Article

Transcription of viral late genes is dependent on expression of the viral intermediate gene G8R in cells infected with an inducible conditional-lethal mutant vaccinia virus.

Journal of virology - 1 Nov 1992

Zhang Y, Keck J G, Moss B

Abstract excerpt

There are three temporal classes of vaccinia virus genes: early, intermediate, and late. The object of this study was to determine the effects on virus replication of regulating the expression of G8R, an intermediate gene that encodes a late transcription factor. We inserted the lac operator adjacent to the RNA start site of the G8R gene in a recombinant vaccinia virus that constitutively expresses the...

Topics

Animals
Base Sequence
DNA, Viral
Enzyme Induction
Gene Expression Regulation, Viral
Genes, Viral
Lac Operon
Molecular Sequence Data
Morphogenesis
Mutation
Operator Regions, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Promoter Regions, Genetic

RNA, Messenger

Repressor Proteins

Transcription Factors

Transcription, Genetic

Transcriptional Activation

Transfection

Source

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Identifiers

PMID: 1404599
DOI: 10.1128/JVI.66.11.6470-6479.1992
PMCID: PMC240139

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1404599-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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