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Article

A dominant mutant form of the herpes simplex virus ICP8 protein decreases viral late gene transcription.

Virology - 15 Jul 1996

Chen Y M, Knipe D M

Abstract excerpt

The herpes simplex virus (HSV) infected cell protein 8 (ICP8) is required for viral DNA replication and normal viral gene expression. Previous work in our laboratory has shown that ICP8 may play a role in stimulating late gene expression. In V2.6 cells which express the d105 mutant form of ICP8, synthesis of late proteins and accumulation of the late gC mRNA are reduced during HSV infection (Gao, M., and Knipe,...

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Source

Identifiers

PMID: 8661438
DOI: 10.1006/viro.1996.0377

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A dominant mutant form of the herpes simplex virus ICP8 protein decreases viral late gene transcription.PMID 8661438Read ↗

Herpes simplex virus 1 ICP27 is required for transcription of two viral late (gamma 2) genes in infected cells.Semantic proximity Read ↗

Potential role for herpes simplex virus ICP8 DNA replication protein in stimulation of late gene expression.Semantic proximity Read ↗

Herpes simplex virus ICP27 increases translation of a subset of viral late mRNAs.Semantic proximity Read ↗

A dominant-negative herpesvirus protein inhibits intranuclear targeting of viral proteins: effects on DNA replication and late gene expression.Semantic proximity Read ↗

The herpes simplex virus regulatory protein ICP27 contributes to the decrease in cellular mRNA levels during infectionSemantic proximity Read ↗

Evidence that the herpes simplex virus immediate early protein ICP27 acts post-transcriptionally during infection to regulate gene expression.Semantic proximity Read ↗

Shuttling of the herpes simplex virus type 1 regulatory protein ICP27 between the nucleus and cytoplasm mediates the expression of late proteins.Semantic proximity Read ↗

Mutations in the activation region of herpes simplex virus regulatory protein ICP27 can be trans dominant.Semantic proximity Read ↗

Herpes simplex virus immediate-early protein ICP22 is required for viral modification of host RNA polymerase II and establishment of the normal viral transcription programSemantic proximity Read ↗

Prolonged gene expression and cell survival after infection by a herpes simplex virus mutant defective in the immediate-early genes encoding ICP4, ICP27, and ICP22Semantic proximity Read ↗

A novel class of transcripts expressed with late kinetics in the absence of ICP4 spans the junction between the long and short segments of the herpes simplex virus type 1 genome.Semantic proximity Read ↗

Herpes simplex ICP27 mutant viruses exhibit reduced expression of specific DNA replication genes.Semantic proximity Read ↗

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