Article
Repression of the A8L gene, encoding the early transcription factor 82-kilodalton subunit, inhibits morphogenesis of vaccinia virions.
Journal of virology - 1 Jan 1998
Hu X, Wolffe E J, Weisberg A S, Carroll L J, Moss B
Abstract excerpt
The vaccinia virus early transcription factor (VETF) is a DNA binding protein comprised of 70- and 82-kDa subunits encoded by the D6R and A8L genes, respectively. A previous investigation suggested a novel role for the 70-kDa subunit in the morphogenesis of vaccinia virus particles. The principal...
Topics
- Animals
- Base Sequence
- Cell Line
- DNA Primers
- DNA, Viral
- DNA-Binding Proteins
- Escherichia coli
- Gene Expression Regulation, Viral
- Genes, Viral
- HeLa Cells
- Humans
- Isopropyl Thiogalactoside
- Lac Operon
- Microscopy, Confocal
- Microscopy, Electron
- Molecular Weight
- Mutation
- Protein Conformation