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Article

Repression of the A8L gene, encoding the early transcription factor 82-kilodalton subunit, inhibits morphogenesis of vaccinia virions.

Journal of virology - 1 Jan 1998

Hu X, Wolffe E J, Weisberg A S, Carroll L J, Moss B

Abstract excerpt

The vaccinia virus early transcription factor (VETF) is a DNA binding protein comprised of 70- and 82-kDa subunits encoded by the D6R and A8L genes, respectively. A previous investigation suggested a novel role for the 70-kDa subunit in the morphogenesis of vaccinia virus particles. The principal objectives of the present study were to determine if the 82-kDa subunit of VETF is also required for morphogenesis...

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Identifiers

PMID: 9420205
DOI: 10.1128/JVI.72.1.104-112.1998
PMCID: PMC109354

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