Point mutations in the Ha-ras oncogene are detectable in formalin-fixed tissues of oral squamous cell carcinomas, but are infrequent in British cases.

doi:10.1111/j.1600-0714.1992.tb00106.x

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Article

Point mutations in the Ha-ras oncogene are detectable in formalin-fixed tissues of oral squamous cell carcinomas, but are infrequent in British cases.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 May 1992

Warnakulasuriya K A, Chang S E, Johnson N W

Abstract excerpt

Oncogene expression in human neoplasia has been examined extensively in the past decade. More recently the advent of the polymerase chain reaction (PCR) has facilitated studies of oncogenes and other DNA structures. Those few studies which have so far searched for oncogene changes in oral cancer have utilized frozen specimens. We report here an adaptation of the PCR technique applicable to DNA extracted from...

Topics

Carcinoma, Squamous Cell
Codon
DNA Probes
DNA, Neoplasm
Female
Gene Amplification
Genes, ras
Glycine
Humans
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mouth Neoplasms

Mutation

Nucleic Acid Hybridization

Polymerase Chain Reaction

United Kingdom

Valine

Source

Open in PubMed

Identifiers

PMID: 1403838
DOI: 10.1111/j.1600-0714.1992.tb00106.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1403838-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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