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Article

Analysis of the c-Ha-ras-1 gene for deletion, mutation, amplification and expression in lymph node metastases of human head and neck carcinomas.

British journal of cancer - 1 Sept 1990

Sheng Z M, Barrois M, Klijanienko J, Micheau C, Richard J M, Riou G

Abstract excerpt

The c-Ha-ras gene was analysed by Southern blot hybridisation in 67 specimens of lymph node metastases and in 25 specimens of primary tumours obtained from 85 untreated patients with head and neck squamous cell carcinoma. The loss of one c-Ha-ras allele was observed in 10/46 (22%) tumours from heterozygous patients for this locus. Different genes, located as the c-Ha-ras gene on the short arm of chromosome 11,...

Topics

Blotting, Northern
Blotting, Southern
Chromosome Deletion
Chromosome Mapping
DNA
Gene Amplification
Genes, ras
Head and Neck Neoplasms
Humans
Lymphatic Metastasis
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins p21(ras)

RNA

Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 1698442
DOI: 10.1038/bjc.1990.306
PMCID: PMC1971465

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1698442-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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