Article
Ras oncogene mutations in thyroid tumors: polymerase chain reaction-restriction-fragment-length polymorphism analysis from paraffin-embedded tissues.
Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Mar 1996
Capella G, Matias-Guiu X, Ampudia X, de Leiva A, Perucho M, Prat J
Abstract excerpt
Ras mutations have been found in thyroid lesions. Different studies have shown different frequencies of mutations among benign and malignant lesions. The presence of point mutations in codons 12 and 13 of the c-K-ras, c-H-ras, and N-ras genes was studied in 58 thyroid lesions (10 nodular goiters,...
Topics
- Adenoma
- Carcinoma, Papillary, Follicular
- Cell Differentiation
- Female
- Genes, ras
- Goiter, Nodular
- Humans
- Hyperplasia
- Male
- Mutation
- Paraffin Embedding
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Thyroid Gland
- Thyroid Neoplasms