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Article

Analysis of ras oncogene mutations in human squamous cell carcinoma of the head and neck.

Surgical oncology - 1 Dec 1992

Núñez F, Domínguez O, Coto E, Suárez-Nieto C, Pérez P, López-Larrea C

Abstract excerpt

The presence of proto-oncogene mutations at codons 12, 13 and 61 of the Ha-, Ki-, and N-ras in primary head and neck squamous cell carcinoma are analysed in this study. Oncogene ras-specific sequences were amplified by the polymerase chain reaction and probed with mutation specific oligonucleotide probes. Mutations were detected in 8 of 22 samples (36.3%). No mutations were detected on patients' peripheral blood...

Topics

Carcinoma, Squamous Cell
Chi-Square Distribution
DNA
Genes, ras
Head and Neck Neoplasms
Humans
Mutation
Neoplasm Staging
Nucleic Acid Hybridization
Oligonucleotide Probes
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Mas

Spain

Survival Analysis

Source

Identifiers

PMID: 1341278
DOI: 10.1016/0960-7404(92)90043-k

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1341278-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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