Article
Analysis of ras oncogene mutations in human squamous cell carcinoma of the head and neck.
Surgical oncology - 1 Dec 1992
Núñez F, Domínguez O, Coto E, Suárez-Nieto C, Pérez P, López-Larrea C
Abstract excerpt
The presence of proto-oncogene mutations at codons 12, 13 and 61 of the Ha-, Ki-, and N-ras in primary head and neck squamous cell carcinoma are analysed in this study. Oncogene ras-specific sequences were amplified by the polymerase chain reaction and probed with mutation specific oligonucleotide probes. Mutations were detected in 8 of 22 samples (36.3%). No mutations were detected on patients' peripheral blood...
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