Absent ras gene mutations in human adrenal cortical neoplasms and pheochromocytomas.

doi:10.1016/s0022-5347(17)36397-8

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Article

Absent ras gene mutations in human adrenal cortical neoplasms and pheochromocytomas.

The Journal of urology - 1 Jun 1993

Moul J W, Bishoff J T, Theune S M, Chang E H

Abstract excerpt

A variety of human tumors have been studied for ras mutations to date. However, little is known about the prevalence and significance of ras gene activation in adrenal neoplasms. Recently, a study of 10 primary human pheochromocytomas found no evidence for ras mutations. To our knowledge no survey of ras mutations in adrenocortical neoplasms has been reported. Therefore, we analyzed deoxyribonucleic acid (DNA)...

Topics

Adrenal Cortex Neoplasms
Adrenal Gland Neoplasms
Blotting, Southern
Carcinoma
Codon
DNA, Neoplasm
Genes, ras
Humans
Mutation
Oligonucleotide Probes
Pheochromocytoma
Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 8501773
DOI: 10.1016/s0022-5347(17)36397-8

Provenance

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