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Article

The absence of Harvey ras mutations during development and progression of squamous cell carcinomas of the head and neck.

British journal of cancer - 1 Sept 1993

Clark L J, Edington K, Swan I R, McLay K A, Newlands W J, Wills L C, Young H A, Johnston P W, Mitchell R, Robertson G

Abstract excerpt

We have examined the incidence of Harvey ras mutations in human squamous cell carcinomas (SCC) of the upper aerodigestive tract using the polymerase chain reaction (PCR) followed by direct sequencing. No mutations were detected at codons 12, 13, 59 or 61 of this gene in any of six papillomas, five erythroplakias, 56 squamous cell carcinomas, and 16 SCC cell lines. Some of the SCC were lymph node metastases...

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Identifiers

PMID: 8353052
DOI: 10.1038/bjc.1993.396
PMCID: PMC1968389

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Source receipt: pubmed, retrieved 7 Sept 2026.

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