Article
High-resolution X-ray study of deoxy recombinant human hemoglobins synthesized from beta-globins having mutated amino termini.
Biochemistry - 15 Sept 1992
Kavanaugh J S, Rogers P H, Arnone A
Abstract excerpt
The crystal structures of three mutant hemoglobins reconstituted from recombinant beta chains and authentic human alpha chains have been determined in the deoxy state at 1.8-A resolution. The primary structures of the mutant hemoglobins differ at the beta-chain amino terminus. One mutant, beta Met, is characterized by the addition of a methionine at the amino terminus. The other two hemoglobins are characterized...
Topics
- Alanine
- Globins
- Hemoglobin A
- Hemoglobins
- Humans
- Macromolecular Substances
- Methionine
- Models, Molecular
- Mutation
- Protein Conformation
- Recombinant Proteins
- Valine